Estradiol Injections

Seller Product Price Single $/mg Bulk $/mg Stock Notes
Inhouse Pharmacy AR Estradiol Valerate 100mg/5ml $475.00 $4.75 $4.75 Unknown
Inhouse Pharmacy AR Estradiol Valerate 200mg/5ml $785.00 $3.92 $3.92 Unknown
Inhouse Pharmacy Depo-Estradiol (EC) 25mg/5ml $500.00 $20.00 $20.00 Unknown
Vanna Pharma Estradiol Cypionate 400mg/10ml $70.00 $0.18 $0.13 Unknown
Silver Maple Labs Estradiol Enanthate 400mg/10ml $70.00 $0.17 $0.17 Yes
TeaHRT Estradiol Undecylate (Castor Oil, no BB) 500mg/5ml $110.00 $0.22 $0.22 Yes
Vanna Pharma Estradiol Undecylate 400mg/10ml $95.00 $0.24 $0.19 Unknown
TeaHRT Estradiol Valerate 400mg/10mL $75.00 $0.19 $0.19 No
Vanna Pharma Estradiol Valerate 400mg/10ml $60.00 $0.15 $0.10 Unknown
4NRX Pharmacy Progynon Depot (EV) 10mg/1ml x 10 £28.86 £0.29 £0.29 No
United Pharmacies (UK) Progynon Depot (EV) 10mg/1ml x 10 £24.66 $0.25 $0.22 No
Japan Health Center (Bio-Japan) Progynon Depot (EV) 10mg/1ml x 10 $99.90 $1.00 $1.00 Yes
HealthyAreaStore Progynon Depot (EV) 10mg/1ml x 10 $65.00 $0.65 $0.65 Unknown
United Pharmacies (US) Progynon Depot (EV) 10mg/1ml x 10 $38.85 $0.39 $0.35 No
AstroVials Estradiol Enanthate 400mg/10ml €50.00 $0.12 $0.12 260 days ago Pre ordering items not already produced is usually not a good idea.
AstroVials Estradiol Valerate 400mg/10ml €40.00 $0.10 $0.10 Yes Pre ordering items not already produced is usually not a good idea.
Otokonoko Pharmaceuticals Estradiol Valerate 400mg/10ml $65.00 $0.16 $0.16 260 days ago This seller is currently suffering delays
TeaHRT Estradiol Cypionate 400mg/10mL $95.00 $0.24 $0.24 Yes Janoshik - Test Report (20/10/23)
TeaHRT Estradiol Enanthate 400mg/10ml $80.00 $0.20 $0.20 Yes Janoshik - Test Report (20/10/23)
Otokonoko Pharmaceuticals Estradiol Enanthate 400mg/10ml $75.00 $0.19 $0.19 260 days ago Trans Harm Reduction - Test Report (08/06/22) This seller is currently suffering delays
Vanna Pharma Estradiol Enanthate 400mg/10ml $65.00 $0.16 $0.11 Unknown Trans Harm Reduction - Test Report (10/12/22)
Otokonoko Pharmaceuticals Estradiol Cypionate 400mg/10ml $85.00 $0.21 $0.21 260 days ago Trans Harm Reduction - Test Report (26/06/23) This seller is currently suffering delays

Info

Injections are preferred by many as a cost-effective and reliable means of reaching ideal hormone levels without the side effects and risks of antiandrogens or having to take pills or gel daily which many find annoying.

There are two categories of injectables available. You can purchase pharmaceutical-grade factory Estradiol Valerate and Estradiol Cypionate, but it is very costly, especially for Estradiol Cypionate. Sometimes factory-made injectables are sold in the form of glass ampoules, which you have to break and then draw the dose with a filter needle to use safely. If your dose is 5mg and you break a 10mg ampoule, the remaining dose is wasted.

More commonly used are "homebrew" injectables, which are produced by individuals instead of pharmaceutical companies. All homebrewed injectables listed on this page are prepared using correct aseptic technique, including vial washing, filtering, and autoclaving of the finished solution. We would consider the risk of using homebrewed vials from a reputable seller to be better or comparable to the level of risk from a compounding pharmacy. Homebrew vials, in addition to being cheaper, also allow usage of better esters such as Estradiol Enanthate which you can take every 7 days without having sharp peaks and mood swings which Estradiol Valerate is infamous for.

Esters Explained

The major esters of estradiol used in injections are valerate, cypionate, enanthate, and undecylate. In the same order goes the shortest half-life of five days for valerate to the longest half-life of almost a month for undecylate. The half-life affects how often you need to take the medication.

Dosing and Monitoring

Mono-therapy is one of the best options for trans-feminine HRT the following dosing is for mono-therapy; the lower end of the dose range can be used with an anti-androgen.

Ester Injection Time Dose
Valerate Every five days or less 3-6mg
Cypionate Around every seven days 4-8mg
Enanthate Around every seven days 4-8mg
Enanthate Around every ten days 6-10mg
Undecylate (MCT Oil) Around every twenty one days 15-25mg
Undecylate (Castor Oil) Around every 31 days 40-60mg

Note: Undecylate is poorly understood and frequent blood tests should be done.

Adjusting dosing based on blood testing in 1-2mg steps is the best way to monitor levels on injections. The ideal range is 150-250 pg/ml of estradiol when blood is taken right before the next dose (this is to get numbers when your estradiol levels are the lowest), with testosterone less than 50 ng/dl. Before taking blood tests make sure you have reached a "steady state" on your current dose, steady state means you have given the new dose enough time to not have past doses (or past lack of doses) affect levels, for most esters except undecylate, this is about six weeks (six weeks being the max amount of time it could take to reach steady state). Also know that the formula to convert dose to injection volume is the dose wanted divided by the density of the active ingredient (usually in mg/ml). For example, 4mg at 40mg/ml is 4 over 40 which is 0.1 ml.

Safety and Effects

Due to skipping the first pass effect, and having good bio-availability which allows for monotherapy (no anti-androgen), estradiol injections have the best safety profile compared to other routes.

Injection Safety

We understand that some in the community have concerns over the safety of the injection itself but be assured that injections are safe and extremely difficult to mess up.

Blood Clots

Estradiol in any form can increase blood clot risk, however, for injections the increased risk is largely comparable to cis women (Aly 2020).

Formulations

Valerate

Castor, Benzyl Benzoate, Benzyl Alcohol

MCT Oil, Benzyl Benzoate, Benzyl Alcohol

Arachnis Oil (Discard rest of medication inside ampule)

Cypionate / Enanthate

Cottonseed Oil, Chlorobutanol

MCT Oil, Benzyl Benzoate, Benzyl Alcohol

MCT Oil, Benzyl Benzoate, Benzyl Alcohol

MCT Oil, Benzyl Alcohol

Castor Oil, Benzyl Alcohol

Undecylate

Castor Oil, Benzyl Alcohol

Castor Oil, Benzyl Benzoate, Benzyl Alcohol

MCT Oil, Benzyl Benzoate, Benzyl Alcohol

MCT Oil, Benzyl Alcohol

Make it Yourself

Making your own injectables requires extreme attention to detail and is dangerous if you mess up, but allows you to secure HRT access for you and your friends in advance for decades, regardless of availability of homebrewers/pharma resellers.

Please see the main homebrew page for important safety warnings.

  1. Injection Tutorial
    • A beginner-focused tutorial which makes use of presterilized vials and is fairly robust against dust contamination.
    • Includes bubble point testing procedure.
    • Includes procedure for automating syringe filtering with a vacuum pump.
    • Sterilizing HRT - Covers re-sterilizing existing vials only. (May be useful for communities with anti-homebrew rules.)
    • Estradiol Calculator - Use to calculate estradiol recipes.
    • Vial Lifetime Estimator - Used to help you determine how much to brew at a time.
  2. Advanced Injection Tutorial
    • Covers injections filtered via vacuum bottle top filtering instead of syringe filters.
    • Less resistant to dust contamination.