Progesterone is the primary Progestogen, the secondary group of female sex hormones.

While many clinicians treat synthetic Progestins and bioidentical Progesterone as interchangeable based on older care guidelines, more recent studies show significantly lower risks when using bioidentical Progesterone.

Progesterone is often taken by transfeminine people along with Estradiol for a variety of reasons including improved breast development and improved fat redistribution. There is currently no data supporting its efficacy on those fronts but there are several studies [1, 2, 3] showing significant benefits to mental and emotional function.

This medication is a suppository, which means it is only suitable for rectal or vaginal delivery. If you have a neovagina then seek guidance from your surgeon or other patients as different surgical methods will result in different levels of absorption to that of a natal vagina.

Unlike many other medications on this site these products are produced by private individuals, not pharmaceutical companies, and thus do not have the associated safety guarantees. While we only list providers with a positive reputation within the DIY community it's important to understand these risks so that you can make an informed decision.